When the Bills travel to the Titans to conclude a long Week 5 of the 2020 NFL season on Tuesday night (7 p.m. ET, CBS), one team will likely Tim Beckham Jersey be handed its first lo s, barring an overtime tie.Buffalo (4-0) is trying to stay undefeated for the big Week 6 matchup vs. Kansas City (4-1). Tenne see (3-0), unable to play Pittsburgh (4-0) in Week 4 because of COVID-19 complications, gets a different, delayed shot at another perfect team.The Bills already were prepared to play midweek as they were scheduled to play the Chiefs on Thursday, a game now pushed back to next Monday night. The Titans have been disrupted by limited practice work after a forced bye with their facility closure.Here’s how Sporting News breaks down this unusual marquee matchup along with betting information you need to know for the game:MORE: | Betting odds for Tuesday nightSpread:Bills by 3.5Point total:51.5Odds:Bills -110, Titans -110The Bills started out as bigger favorites but they have been hit with some injuries while the Titans have extra rest on top of a bye. Tenne seewill have some fans at the game, but the Titans’ home field isn’t known for being intimidating. The Bills also are a better overall team.Bills vs. Titans all-time seriesThe Titans, formerly the Houston Oilers, hold a 28-19 edge over the Bills. They have a great playoff history that includes the Titans’ Music City Miracle and the Bills’ epic comeback with Frank Reich vs. the Oilers. The Bills have won three straight low-scoring games, 14-7 last year, 13-12in 2018 and 14-13 in 2015. Before that, the Bills had dropped five consecutive matchups and eight of nine.Three trends to know 60 percent of Mark Trumbo Jersey over/under bettors like the total to go over with two strong offenses and two hurting defenses. 51 percent of spread bettors like the Bills to take care of the low number as road favorites. The Bills are 3-1 against the spread this season. The Titans are 0-3 against the spread. The total has gone over in five of the teams’combined seven games.MORE: Three things to watchThe Bills’ injuriesOffensively, quarterback Josh Allen (left shoulder) and wide receiver Cole Beasley (foot) will play. Wide receiver John Brown (knee;questionable), running back Zack Mo s (toe;questionable) and left guard Cody Ford (groinl;questionable) all have a good chance Adam Jones Jersey to play. Defensively, Buffalo will be without linebacker Matt Milano (pectoral;out) again and shutdown cornerback Tre’Davious White (back;questionable) is iffy after not practicing all week.Allen has looked good in practice and should continue his red-hot start with his great connection with new go-to wideout Stefon Diggs. The Titans cannot cover Diggs, Brown or rookie Gabriel Davis downfield on the outside.The Titans’ injuriesThe Titans are getting a break with the extra time as both wide receiver A.J. Brown (knee;questionable) and left tackle Taylor Lewan (shoulder;questionable) are expected to play. Brown’s presence could be huge with White hurting and the Bills needing to reshuffle No. 2 corner without Levi Wallace. Also look for tight end Jonnu Smith to be effective for quarterback Ryan Tannehill,taking advantage of Milano’s absence.Devin Singletary vs. Derrick HenrySingletary, after two strong games, might get help in the Bills’ backfield from Mo s. Henry continues to see high volume and will be well rested to see another heavy workload. The Bills have been aggre sive downfield pa sing to facilitate the run, while the Titans need the threat of Henry to set up the deep pa sing off play-action for Tannehill.Stats that matter256.3 and Trey Mancini Jersey 280.2. The first number is how many pa sing yards per game on average the Titans give up, No. 23 in the NFL. The second number is the Bills’ mark, ranked 29th in the league. The Titans’ secondary is shot and they’re not getting much pa s rush. The Bills are struggling in the back end and might not have White to shut down one side and will mi s Milano in coverage, too.But it’s easier to trust Allen in the downfield pa sing game than Tannehill, based on how both QBs are playing.Bills vs. Titans predictionThe Bills have le s disruption and should welcome having a little more time before they need to worry about the Chiefs. Allen is playing too well at the moment to think the Titans’ slow defense can keep him from throwing and, at times, running at full speed. The Bills win with more firepower and more sound defensive play.Bills Roberto Alomar Jersey 27, Titans 20…